EC 220.127.116.11 - ADAM10 endopeptidase
IntEnz Enzyme Nomenclature
myelin-associated disintegrin metalloproteinase
- Endopeptidase of broad specificity.
In peptidase family M12. Partially responsible for the "α-secretase" activity in brain that degrades the potentially harmful β-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
Links to other databases
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.FASEB J. 17: 292-294 (2003). [PMID: 12475894]
[EC 18.104.22.168 created 2003]