EC 18.104.22.168 - Oligopeptidase A
IntEnz Enzyme Nomenclature
- Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly┼Gly-Pro-Ala is cleaved, but not Z-(Gly)5 .
Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, in peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation.
Links to other databases
Degradation of a signal peptide by protease IV and oligopeptidase A.J. Bacteriol. 170: 5067-5075 (1988). [PMID: 3053642]
Oligopeptidase A is required for normal phage P22 development.J. Bacteriol. 174: 5869-5880 (1992). [PMID: 1522065]
Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene.J. Bacteriol. 174: 5881-5887 (1992). [PMID: 1325967]
Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium.Methods Enzymol. 248: 567-579 (1995). [PMID: 7674945]
[EC 22.214.171.124 created 1996]