EC - Oligopeptidase A

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IntEnz Enzyme Nomenclature


Accepted name:
oligopeptidase A
Other name:
68000-M signalpeptide hydrolase
Systematic name:




Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, in peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008944
CAS Registry Number: 148266-37-9


  1. Novak, P. and Dev, I.K.
    Degradation of a signal peptide by protease IV and oligopeptidase A.
    J. Bacteriol. 170: 5067-5075 (1988). [PMID: 3053642]
  2. Conlin, C.A., Vimr, E.R. and Miller, C.G.
    Oligopeptidase A is required for normal phage P22 development.
    J. Bacteriol. 174: 5869-5880 (1992). [PMID: 1522065]
  3. Conlin, C.A., Trun, N.J., Silhavy, T.J. and Miller, C.G.
    Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene.
    J. Bacteriol. 174: 5881-5887 (1992). [PMID: 1325967]
  4. Conlin, C.A. and Miller, C.G.
    Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium.
    Methods Enzymol. 248: 567-579 (1995). [PMID: 7674945]

[EC created 1996]