EC 126.96.36.199 - Mitochondrial processing peptidase
IntEnz Enzyme Nomenclature
matrix processing peptidase
matrix processing proteinase
mitochondrial protein precursor-processing proteinase
processing enhancing peptidase (for one of two subunits)
processing enhancing peptidase
- Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
Known from the mitochondrial matrix of fungi and mammals. Formed from two subunits, both homologous with pitrilysin , and the products of the MAS1 and MAS2 genes in yeast. In peptidase family M16 (pitrilysin family). Formerly EC 188.8.131.52.
Links to other databases
Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit.EMBO J. 7: 3863-3871 (1988). [PMID: 3061808]
MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease.EMBO J. 7: 1439-1447 (1988). [PMID: 3044780]
Homologues of insulinase, a new superfamily of metalloendopeptidases.Biochem. J. 275: 389-391 (1991). [PMID: 2025223]
Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins.Trends Biochem. Sci. 18: 249 (1993). [PMID: 8212133]
Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa.Methods Enzymol. 248: 717-728 (1994).
[EC 184.108.40.206 created 1989/90 as EC 220.127.116.11, transferred 1995 to EC 18.104.22.168]