EC 188.8.131.52 - Meprin B
IntEnz Enzyme Nomenclature
- Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5┼Leu-, -Leu6┼Cys-, -Ala14┼Leu- and -Cys19┼Gly- bonds in insulin B chain.
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin b subunits (in contrast to meprin A, which contains both a and b subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family).
Links to other databases
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.J. Biol. Chem. 266: 17350-17357 (1991). [PMID: 1894622]
Cloning, expression, and chromosomal localization of the mouse meprin β subunit.J. Biol. Chem. 268: 21035-21043 (1993). [PMID: 8407940]
Expression of meprin subunit precursors. Membrane anchoring through the β subunit and mechanism of zymogen activation.J. Biol. Chem. 269: 7682-7688 (1994). [PMID: 14171803]
Meprins A and B.Methods Enzymol. 248: 325-345 (1995). [PMID: 7674930]
[EC 184.108.40.206 created 1995]