EC 18.104.22.168 - Nardilysin
IntEnz Enzyme Nomenclature
- Hydrolysis of polypeptides, preferably at -Xaa┼Arg-Lys-, and less commonly at -Arg┼Arg-Xaa-, in which Xaa is not Arg or Lys.
Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family).
Links to other databases
The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes.J. Biol. Chem. 260: 10541-10545 (1985). [PMID: 3897221]
Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.J. Biol. Chem. 262: 9615-9620 (1987). [PMID: 2885328]
Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues.J. Biol. Chem. 269: 2056-2061 (1994). [PMID: 8294457]
N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.Proc. Natl. Acad. Sci. USA 91: 6078-6082 (1994). [PMID: 8016118]
[EC 22.214.171.124 created 1995]