EC 3.4.24.59 - Mitochondrial intermediate peptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.59

Names

Accepted name:
mitochondrial intermediate peptidase
Other names:
MIP
mitochondrial intermediate precursor-processing proteinase
Systematic name:

Reaction

Cofactor

Comments:

A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004243
CAS Registry Number: 136447-30-8
UniProtKB/Swiss-Prot: (45) [show] [UniProt]

References

  1. Isaya, G., Kalousek, F. and Rosenberg, L.E.
    Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase.
    J. Biol. Chem. 267: 7904-7910 (1992). [PMID: 1560019]
  2. Isaya, G., Kalousek, F. and Rosenberg, L.E.
    Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue.
    Proc. Natl. Acad. Sci. USA 89: 8317-8321 (1992). [PMID: 1518864]

[EC 3.4.24.59 created 1993]