EC 188.8.131.52 - O-sialoglycoprotein endopeptidase
IntEnz Enzyme Nomenclature
- Hydrolysis of O-sialoglycoproteins; cleaves -Arg31┼Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.
An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22.
Links to other databases
Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.J. Bacteriol. 173: 5597-5603 (1991). [PMID: 1885539]
A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins.Infect. Immun. 60: 56-62 (1992). [PMID: 1729196]
Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica.J. Immunol. 148: 1458-1464 (1992). [PMID: 1371528]
[EC 184.108.40.206 created 1993]