EC 3.4.24.57 - O-sialoglycoprotein endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.57

Names

Accepted name:
O-sialoglycoprotein endopeptidase
Other names:
glycophorin A proteinase
glycoprotease
glycoproteinase
sialoglycoprotease
sialoglycoproteinase
Systematic name:

Reaction

Comments:

An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00779
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008450
CAS Registry Number: 129430-53-1

References

  1. Abdullah, K.M., Lo, R.Y.C. and Mellors, A.
    Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
    J. Bacteriol. 173: 5597-5603 (1991). [PMID: 1885539]
  2. Abdullah, K.M., Udoh, E.A., Shewen, P.E. and Mellors, A.
    A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins.
    Infect. Immun. 60: 56-62 (1992). [PMID: 1729196]
  3. Sutherland, D.R., Abdullah, K.M., Cyopick, P. and Mellors, A.
    Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica.
    J. Immunol. 148: 1458-1464 (1992). [PMID: 1371528]

[EC 3.4.24.57 created 1993]