EC 220.127.116.11 - Matrilysin
IntEnz Enzyme Nomenclature
matrix metalloproteinase 7
matrix metalloproteinase pump 1
putative (or punctuated) metalloproteinase-1
- Cleavage of Ala14┼Leu and Tyr16┼Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain α2(I) > α1(I).
Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll.
Links to other databases
The collagenase gene family in humans consists of at least four members.Biochem. J. 253: 187-192 (1988). [PMID: 2844164]
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.J. Biol. Chem. 263: 16918-16925 (1988). [PMID: 3182822]
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.Biochemistry 28: 5327-5334 (1989). [PMID: 2550050]
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.Cancer Res. 50: 7758-7764 (1990). [PMID: 2253219]
[EC 18.104.22.168 created 1992]