EC 3.4.24.23 - Matrilysin

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IntEnz Enzyme Nomenclature
EC 3.4.24.23

Names

Accepted name:
matrilysin
Other names:
MMP
MMP 7
PUMP
PUMP-1 proteinase
matrin
matrix metalloproteinase 7
matrix metalloproteinase pump 1
metalloproteinase pump-1
putative (or punctuated) metalloproteinase-1
putative metalloproteinase
uterine metalloendopeptidase
Systematic name:

Reaction

Cofactors

Comments:

Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004235
CAS Registry Number: 141256-52-2
UniProtKB/Swiss-Prot:

References

  1. Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R.
    The collagenase gene family in humans consists of at least four members.
    Biochem. J. 253: 187-192 (1988). [PMID: 2844164]
  2. Woessner, J.F., Jr and Taplin, C.J.
    Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
    J. Biol. Chem. 263: 16918-16925 (1988). [PMID: 3182822]
  3. Quantin, B., Murphy, G. and Breathnach, R.
    Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.
    Biochemistry 28: 5327-5334 (1989). [PMID: 2550050]
  4. Miyazaki, K., Hattori, Y., Umenishi, F., Yasumitsu, H. and Umeda, M.
    Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
    Cancer Res. 50: 7758-7764 (1990). [PMID: 2253219]

[EC 3.4.24.23 created 1992]