EC 220.127.116.11 - Neurolysin
IntEnz Enzyme Nomenclature
- Preferential cleavage in neurotensin: Pro10┼Tyr.
No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family).
Links to other databases
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.J. Biol. Chem. 261: 11274-11281 (1986). [PMID: 3525564]
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum.Eur. J. Biochem. 175: 481-489 (1988). [PMID: 3409880]
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies.Biochem. J. 257: 549-554 (1989). [PMID: 2649078]
[EC 18.104.22.168 created 1989]