EC 3.4.23.46 - Memapsin 2

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IntEnz Enzyme Nomenclature
EC 3.4.23.46

Names

Accepted name:
memapsin 2
Other names:
β-secretase [ambiguous]
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
β-site APP-cleaving enzyme 1
membrane-associated aspartic protease 2
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1
BACE1
Systematic name:
-

Reaction

Comments:

Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Turner, R.T., III, Koelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J.
    Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design.
    Biochemistry 40: 10001-10006 (2001). [PMID: 11513577]
  2. Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J.
    Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3.
    Biochemistry 41: 10963-10967 (2002). [PMID: 12206667]

[EC 3.4.23.46 created 2003]