EC 220.127.116.11 - Memapsin 2
IntEnz Enzyme Nomenclature
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
β-site APP-cleaving enzyme 1
membrane-associated aspartic protease 2
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1
- Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
Links to other databases
Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design.Biochemistry 40: 10001-10006 (2001). [PMID: 11513577]
Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3.Biochemistry 41: 10963-10967 (2002). [PMID: 12206667]
[EC 18.104.22.168 created 2003]