EC 3.4.23.45 - Memapsin 1

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IntEnz Enzyme Nomenclature
EC 3.4.23.45

Names

Accepted name:
memapsin 1
Other names:
β-secretase [ambiguous]
β-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2)
ASP1
Down region aspartic protease
β-site Alzheimer's amyloid precursor protein cleaving enzyme 2
membrane-associated aspartic protease 1
BACE2
β-site APP-cleaving enzyme 2
Systematic name:
-

Reaction

Comments:

Can cleave β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Turner, R.T., Loy, J.A., Nguyen, C., Devasamudram, T., Ghosh, A.K., Koelsch, G. and Tang, J.
    Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity.
    Biochemistry 41: 8742-8746 (2002). [PMID: 12093293]

[EC 3.4.23.45 created 2003]