EC - Signal peptidase II

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IntEnz Enzyme Nomenclature


Accepted name:
signal peptidase II
Other names:
leader peptidase II
premurein leader proteinase
premurein-leader peptidase
prolipoprotein signal peptidase
Systematic name:



An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00669
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009005
CAS Registry Number: 171715-14-3
UniProtKB/Swiss-Prot: (421) [show] [UniProt]


  1. Dev, I.K. and Ray, P.H.
    Signal peptidases and signal peptide hydrolases.
    J. Bioenerg. Biomembr. 22: 271-290 (1990).
  2. Zhao, X.-J. and Wu, H.C.
    Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene.
    FEBS Lett. 299: 80-84 (1992). [PMID: 1544479]
  3. Sankaran, K. and Wu, H.C.
    Bacterial prolipoprotein signal peptidase.
    Methods Enzymol. 248: 169-180 (1995). [PMID: 7674920]

[EC created 1984 as EC, transferred 1995 to EC]