EC 3.4.23.36 - Signal peptidase II

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.4.23.36

Names

Accepted name:
signal peptidase II
Other names:
leader peptidase II
premurein leader proteinase
premurein-leader peptidase
prolipoprotein signal peptidase
Systematic name:

Reaction

Comments:

An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8. Formerly EC 3.4.99.35.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00669
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009005
CAS Registry Number: 171715-14-3
UniProtKB/Swiss-Prot: (421) [show] [UniProt]

References

  1. Dev, I.K. and Ray, P.H.
    Signal peptidases and signal peptide hydrolases.
    J. Bioenerg. Biomembr. 22: 271-290 (1990).
  2. Zhao, X.-J. and Wu, H.C.
    Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene.
    FEBS Lett. 299: 80-84 (1992). [PMID: 1544479]
  3. Sankaran, K. and Wu, H.C.
    Bacterial prolipoprotein signal peptidase.
    Methods Enzymol. 248: 169-180 (1995). [PMID: 7674920]

[EC 3.4.23.36 created 1984 as EC 3.4.99.35, transferred 1995 to EC 3.4.23.36]