EC 3.4.23.3 - Gastricsin

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IntEnz Enzyme Nomenclature
EC 3.4.23.3

Names

Accepted name:
gastricsin
Other names:
parapepsin II
pepsin C
pig parapepsin II
Systematic name:

Reaction

Comments:

Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family). Formerly EC 3.4.4.22.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
CAS Registry Number: 9012-71-9
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Ryle, A.P.
    The porcine pepsins and pepsinogens.
    Methods Enzymol. 19: 316-336 (1970).
  2. Tang, J.
    Gastricsin and pepsin.
    Methods Enzymol. 19: 406-421 (1970).
  3. Foltmann, B.
    Gastric proteinases - structure, function, evolution and mechanism of action.
    Essays Biochem. 17: 52-84 (1981). [PMID: 6795036]
  4. Foltmann, B. and Jensen, A.L.
    Human progastricsin - analysis of intermediates during activation into gastricsin and determination of the amino-acid sequence of the propart.
    Eur. J. Biochem. 128: 63-70 (1982). [PMID: 6816595]
  5. Martin, P., Trieu-Cuot, P., Collin, J.-C. and Ribadeau Dumas, B.
    Purification and characterization of bovine gastricsin.
    Eur. J. Biochem. 122: 31-39 (1982). [PMID: 6800788]
  6. Reid, W.A., Vongsorasak, L., Svasti, J., Valler, M.J. and Kay J.
    Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
    Cell Tissue Res. 236: 597-600 (1984). [PMID: 6432332]
  7. Hayano, T., Sogawa, K., Ichihara, Y., Fujii-Kuriyama, Y. and Takahasi, K.
    Primary structure of human pepsinogen C gene.
    J. Biol. Chem. 263: 1382-1385 (1988). [PMID: 3335549]

[EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986]