EC 3.4.22.52 - Calpain-1

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IntEnz Enzyme Nomenclature
EC 3.4.22.52

Names

Accepted name:
calpain-1
Other names:
μ-calpain
calcium-activated neutral protease I
Systematic name:
-

Reaction

Cofactor

Comments:

In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 78990-62-2
UniProtKB/Swiss-Prot:

References

  1. Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S.
    Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain.
    Biochem. J. 367: 263-269 (2002). [PMID: 12014988]

[EC 3.4.22.52 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.52]