EC 3.4.22.49 - Separase

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IntEnz Enzyme Nomenclature
EC 3.4.22.49

Names

Accepted name:
separase
Other name:
separin
Systematic name:
-

Reaction

Comments:

In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Waizenegger, I., Gimenez-Abian, J., Wernic, D. and Peters, J.
    Regulation of human separase by securin binding and autocleavage.
    Curr. Biol. 12: 1368-1378 (2002). [PMID: 12194817]

[EC 3.4.22.49 created 2003]