EC 188.8.131.52 - Helper-component proteinase
IntEnz Enzyme Nomenclature
- Hydrolyses a Gly┼Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly┼Gly, in the processing of the potyviral polyprotein.
Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6.
Links to other databases
Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus.Virology 209: 268-273 (1995).
Potyvirus helper component proteinase.In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 677-679
[EC 184.108.40.206 created 2001]