EC - Helper-component proteinase

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IntEnz Enzyme Nomenclature


Accepted name:
helper-component proteinase
Other name:
Systematic name:



Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (62) [show] [UniProt]


  1. Kasschau, K.D. and Carrington, J.C.
    Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus.
    Virology 209: 268-273 (1995).
  2. Verchot, J.
    Potyvirus helper component proteinase.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 677-679

[EC created 2001]