EC 22.214.171.124 - Cathepsin V
IntEnz Enzyme Nomenclature
- The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2.
Links to other databases
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.Biochemistry 38: 2377-2385 (1999). [PMID: 10029531]
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.Invest. Ophthalmol. Vis. Sci. 39: 1789-1796 (1998). [PMID: 9727401]
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.Cancer Res. 58: 1624-1630 (1998). [PMID: 9563472]
[EC 126.96.36.199 created 2000]