EC 3.4.22.43 - Cathepsin V

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IntEnz Enzyme Nomenclature
EC 3.4.22.43

Names

Accepted name:
cathepsin V
Other names:
cathepsin L2
cathepsin U
Systematic name:
-

Reaction

Comments:

Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Brömme, D., Li, Z., Barnes, M. and Mehler, E.
    Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
    Biochemistry 38: 2377-2385 (1999). [PMID: 10029531]
  2. Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K., and Okubo, K.
    Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.
    Invest. Ophthalmol. Vis. Sci. 39: 1789-1796 (1998). [PMID: 9727401]
  3. Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C.
    Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
    Cancer Res. 58: 1624-1630 (1998). [PMID: 9563472]

[EC 3.4.22.43 created 2000]