EC 220.127.116.11 - Cathepsin K
IntEnz Enzyme Nomenclature
cathepsin X [ambiguous]
- Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family).
Links to other databases
Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone.Biochem. Biophys. Res. Commun. 206: 89-96 (1995). [PMID: 7818555]
Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification.J. Biol. Chem. 271: 12517-12524 (1996). [PMID: 8647860]
Peptidyl vinyl sulphones: A new class of potent and selective cysteine protease inhibitors - S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.Biochem. J. 315: 85-89 (1996). [PMID: 8670136]
Crystal structure of human osteoclast cathepsin K complex with E-64.Nature Struct. Biol. 4: 109-111 (1997). [PMID: 9033588]
Crystal structure of human cathepsin K complexed with a potent inhibitor.Nature Struct. Biol. 4: 105-109 (1997). [PMID: 9033587]
[EC 18.104.22.168 created 1997]