EC 3.4.22.36 - Caspase-1

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IntEnz Enzyme Nomenclature
EC 3.4.22.36

Names

Accepted name:
caspase-1
Other names:
ICE
interleukin 1 converting enzyme
interleukin 1β precursor proteinase
interleukin 1β-converting endopeptidase
interleukin 1β-converting enzyme
interleukin-1β convertase
interleukin-1β converting enzyme
interleukin-1β precursor proteinase
precursor interleukin-1β converting enzyme
pro-interleukin 1β proteinase
prointerleukin 1β protease
protease A
protease VII
interleukin-1 β convertase precursor
interleukin 1β converting enzyme
Systematic name:
-

Reaction

Comments:

From mammalian monocytes. This enzyme is part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00864
Structural data: CSA , EC2PDB
CAS Registry Number: 122191-40-6
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Howard, A., Kostura, M.J., Thornberry, N., Ding, G.J., Limjuco, G., Weidner, J., Salley, J.P., Hogquist, K.A., Chaplin, D.D., Mumford, R.A., Schmidt, J.A. and Tocci, M.J.
    IL-1 converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α.
    J. Immunol. 147: 2964-2969 (1991). [PMID: 1919001]
  2. Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., Elliston, K.O., Ayala, J.M., Casano, F J., Chin, J., Ding, G.J.-F., Egger, L.A., Gaffney, E.P., Limjuco, G., Palyha, O.C., Raju, S.M., Rolando, A.M., Salley, J.P., Yamin, T.-T. and Tocci, M.J.
    A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes.
    Nature 356: 768-774 (1992). [PMID: 1574116]
  3. Thornberry, N.A.
    Interleukin-1β converting enzyme.
    Methods Enzymol. 244: 615-631 (1994). [PMID: 7845238]
  4. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W. and Yuan, J.Y.
    Human ICE/CED-3 protease nomenclature.
    Cell 87: 171 (1996). [PMID: 8861900]
  5. Margolin, N., Raybuck, S.A., Wilson, K.P., Chen, W.Y., Fox, T., Gu, Y. and Livingston, D.J.
    Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases.
    J. Biol. Chem. 272: 7223-7228 (1997). [PMID: 9054418]
  6. Martinon, F. and Tschopp, J.
    Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
    Cell 117: 561-574 (2004). [PMID: 15163405]
  7. Chang, H.Y. and Yang, X.
    Proteases for cell suicide: functions and regulation of caspases.
    Microbiol. Mol. Biol. Rev. 64: 821-846 (2000). [PMID: 11104820]

[EC 3.4.22.36 created 1993, modified 1997, modified 2007]