EC 3.4.22.34 - Legumain

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IntEnz Enzyme Nomenclature
EC 3.4.22.34

Names

Accepted name:
legumain
Other names:
PRSC1 gene product (Homo sapiens)
asparaginyl endopeptidase
bean endopeptidase
citvac
hemoglobinase [ambiguous]
proteinase B [ambiguous]
vicilin peptidohydrolase
Systematic name:
-

Reaction

Comments:

Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
Gene Ontology: GO:0001509
CAS Registry Number: 149371-18-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]

References

  1. Hara-Nishimura, I.
    Asparaginyl endopeptidase.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 746-749
  2. Dalton, J.P. and Brindley, P.J.
    Schistosome legumain.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1988, 749-754
  3. Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J.
    Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
    FEBS Lett. 441: 361-365 (1998). [PMID: 9891971]

[EC 3.4.22.34 created 1992, modified 2000]