EC 3.4.22.33 - Fruit bromelain

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IntEnz Enzyme Nomenclature
EC 3.4.22.33

Names

Accepted name:
fruit bromelain
Other names:
ananase
bromelase
bromelin
extranase
fruit bromelain FA2
juice bromelain
pinase
pineapple enzyme
traumanase
Systematic name:

Reaction

Comments:

From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain (formerly EC 3.4.99.18), is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin [4]. In peptidase family C1 (papain family). Formerly EC 3.4.22.5 and included in EC 3.4.22.4.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 9001-00-7
UniProtKB/Swiss-Prot:

References

  1. Sasaki, M., Kato, T. and Iida, S.
    Antigenic determinant common to four kinds of thiol proteases of plant origin.
    J. Biochem. (Tokyo) 74: 635-637 (1973). [PMID: 4127920]
  2. Yamada, F., Takahashi, N. and Murachi, T.
    Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2.
    J. Biochem. (Tokyo) 79: 1223-1234 (1976). [PMID: 956152]
  3. Ota, S., Muta, E., Katanita, Y. and Okamoto, Y.
    Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains.
    J. Biochem. (Tokyo) 98: 219-228 (1985). [PMID: 4044551]
  4. Rowan, A.D., Buttle, D.J. and Barrett, A.J.
    The cysteine proteinases of the pineapple plant.
    Biochem. J. 266: 869-875 (1990). [PMID: 2327970]

[EC 3.4.22.33 created 1965 as EC 3.4.4.24, transferred 1972 to EC 3.4.22.4, part transferred 1992 to EC 3.4.22.33]