EC 184.108.40.206 - Assemblin
IntEnz Enzyme Nomenclature
- Cleaves -Ala┼Ser- and -Ala┼Ala- bonds in the scaffold protein.
Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. Inhibited by diisopropyl fluorophosphate. Type example of peptidase family S21. Catalytic residues are His, Ser, His, a combination not known for any other peptidase, and the protein fold also is unique. Known from herpes viruses of several types, cytomegalovirus, Epstein-Barr virus and human herpesvirus 3.
Links to other databases
Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad.Cell 86: 477-483 (1996). [PMID: 8797829]
Herpesvirus assemblin.In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 470-472
[EC 220.127.116.11 created 2000]