EC 3.4.21.94 - Proprotein convertase 2

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IntEnz Enzyme Nomenclature
EC 3.4.21.94

Names

Accepted name:
proprotein convertase 2
Other names:
PC2
neuroendocrine convertase 2
Systematic name:
-

Reaction

Comments:

A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004286
CAS Registry Number: 388092-42-0
UniProtKB/Swiss-Prot:

References

  1. Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. and Chrétien, M.
    cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
    DNA Cell Biol. 9: 415-424 (1990). [PMID: 2169760]
  2. Smeekens, S.P. and Steiner, D.F.
    Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
    J. Biol. Chem. 265: 2997-3000 (1990). [PMID: 2154467]
  3. Rouillé, Y., Westermark, G., Martin, S.K. and Steiner, D.F.
    Proglucagon is processed to glucagon by prohormone convertase PC2 in αTC1-6 cells.
    Proc. Natl. Acad. Sci. USA 91: 3242-3246 (1994). [PMID: 8159732]
  4. Seidah, N.G. and Chrétien, M.
    Pro-protein convertases of the subtilisin/kexin family.
    Methods Enzymol. 244: 175-188 (1994). [PMID: 7845206]

[EC 3.4.21.94 created 1996]