EC 22.214.171.124 - Proprotein convertase 1
IntEnz Enzyme Nomenclature
neuroendocrine convertase 1
prohormone convertase 3
prohormone convertase I
- Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg┼ bonds.
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family).
Links to other databases
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.DNA Cell Biol. 9: 415-424 (1990). [PMID: 2169760]
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.Proc. Natl. Acad. Sci. USA 88: 340-344 (1991). [PMID: 1988934]
The new enzymology of precursor processing endoproteases.J. Biol. Chem. 267: 23435-23438 (1992). [PMID: 1429684]
Pro-protein convertases of the subtilisin/kexin family.Methods Enzymol. 244: 175-188 (1994). [PMID: 7845206]
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.Biochem. J. 307: 689-695 (1995). [PMID: 7741698]
[EC 126.96.36.199 created 1996]