EC 188.8.131.52 - Granzyme B
IntEnz Enzyme Nomenclature
cytotoxic cell proteinase-1
- Preferential cleavage: -Asp┼ >> -Asn┼ > -Met┼, -Ser┼.
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family).
Links to other databases
Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes.J. Immunol. 139: 250-256 (1987). [PMID: 2953813]
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.Biochemistry 30: 2217-2227 (1991). [PMID: 1998680]
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.J. Biol. Chem. 266: 98-103 (1991). [PMID: 1985927]
[EC 184.108.40.206 created 1993]