EC - Granzyme B

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IntEnz Enzyme Nomenclature


Accepted name:
granzyme B
Other names:
CCP1 proteinase
cytotoxic cell proteinase-1
granzyme G
granzyme H
Systematic name:



From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004278
CAS Registry Number: 143180-74-9


  1. Schmid, J. and Weissmann, C.
    Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes.
    J. Immunol. 139: 250-256 (1987). [PMID: 2953813]
  2. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
    Biochemistry 30: 2217-2227 (1991). [PMID: 1998680]
  3. Poe, M., Blake, J.T., Boulton, D.A., Gammon, M., Sigal, N.H., Wu, J.K. and Zweerink, H.J.
    Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
    J. Biol. Chem. 266: 98-103 (1991). [PMID: 1985927]

[EC created 1993]