EC 3.4.21.78 - Granzyme A

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.4.21.78

Names

Accepted name:
granzyme A
Other names:
CTLA3
HuTPS
T-cell associated protease 1
T-cell derived serine proteinase
TSP-1
cytotoxic T lymphocyte serine protease
Systematic name:

Reaction

Comments:

From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe┼-.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004277
CAS Registry Number: 143180-73-8
UniProtKB/Swiss-Prot:

References

  1. Simon, M.M., Hoschützky, H., Fruth, U., Simon, H.-G. and Kramer, M.D.
    Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.
    EMBO J. 5: 3267-3274 (1986). [PMID: 3545816]
  2. Gershenfeld, H.K., Hershberger, R.J., Shows, T.B. and Weissman, I.L.
    Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
    Proc. Natl. Acad. Sci. USA 85: 1184-1188 (1988). [PMID: 3257574]
  3. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
    Biochemistry 30: 2217-2227 (1991). [PMID: 1998680]

[EC 3.4.21.78 created 1993]