EC 18.104.22.168 - Granzyme A
IntEnz Enzyme Nomenclature
T-cell associated protease 1
T-cell derived serine proteinase
cytotoxic T lymphocyte serine protease
- Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg┼, -Lys┼ >> -Phe┼ in small molecule substrates.
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe┼-.
Links to other databases
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.EMBO J. 5: 3267-3274 (1986). [PMID: 3545816]
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.Proc. Natl. Acad. Sci. USA 85: 1184-1188 (1988). [PMID: 3257574]
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.Biochemistry 30: 2217-2227 (1991). [PMID: 1998680]
[EC 22.214.171.124 created 1993]