EC 3.4.21.72 - IgA-specific serine endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.21.72

Names

Accepted name:
IgA-specific serine endopeptidase
Other names:
IgA protease
IgA proteinase
IgA-specific proteinase
immunoglobulin A protease
immunoglobulin A proteinase
Systematic name:
-

Reaction

Comments:

Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 55127-02-1
UniProtKB/Swiss-Prot:

References

  1. Plaut, A.G.
    The IgA1 proteases of pathogenic bacteria.
    Annu. Rev. Microbiol. 37: 603-622 (1983). [PMID: 6416146]
  2. Bachovchin, W.W., Plaut, A.G., Flentke, G.R., Lynch, M. and Kettner, C.A.
    Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
    J. Biol. Chem. 265: 3738-3743 (1990). [PMID: 2105953]

[EC 3.4.21.72 created 1992]