EC - IgA-specific serine endopeptidase

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IntEnz Enzyme Nomenclature


Accepted name:
IgA-specific serine endopeptidase
Other names:
IgA protease
IgA proteinase
IgA-specific proteinase
immunoglobulin A protease
immunoglobulin A proteinase
Systematic name:



Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC, IgA-specific metalloendopeptidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 55127-02-1


  1. Plaut, A.G.
    The IgA1 proteases of pathogenic bacteria.
    Annu. Rev. Microbiol. 37: 603-622 (1983). [PMID: 6416146]
  2. Bachovchin, W.W., Plaut, A.G., Flentke, G.R., Lynch, M. and Kettner, C.A.
    Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
    J. Biol. Chem. 265: 3738-3743 (1990). [PMID: 2105953]

[EC created 1992]