EC - Protein C (activated)

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IntEnz Enzyme Nomenclature


Accepted name:
protein C (activated)
Other names:
activated blood coagulation factor XIV
activated protein C
autoprothrombin II-A
blood-coagulation factor XIVa
protein Ca
autoprothrombin IIA
Systematic name:



A peptidase of family S1 (trypsin family), one of the γ-carboxyglutamic acid-containing coagulation factors. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003808
CAS Registry Number: 42617-41-4 (not distinguished from EC
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Esmon, C.T.
    The regulation of natural anticoagulant pathways.
    Science 235: 1348-1352 (1987). [PMID: 3029867]
  2. Esmon, C.T.
    The roles of protein C and thrombomodulin in the regulation of blood coagulation.
    J. Biol. Chem. 264: 4743-4746 (1989). [PMID: 2538457]

[EC created 1992]