EC 18.104.22.168 - T-plasminogen activator
IntEnz Enzyme Nomenclature
tissue plasminogen activator
tissue-type plasminogen activator
- Specific cleavage of Arg┼Val bond in plasminogen to form plasmin.
A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 22.214.171.124 and EC 126.96.36.199.
Links to other databases
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.Nature 301: 214-221 (1983). [PMID: 6337343]
Plasminogen activators and their inhibitors.Methods Enzymol. 163: 293-302 (1988). [PMID: 3148826]
The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage.Biochim. Biophys. Acta 952: 245-254 (1988). [PMID: 2962643]
Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma.Methods Enzymol. 163: 302-309 (1988). [PMID: 3148827]
Regulation of tissue plasminogen activator expression.Annu. Rev. Physiol. 51: 245-262 (1989). [PMID: 2496643]
The fibrinolytic system and its disorders.In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.) Blood: Principles and Practice of Hematology, 2nd ed., J.B. Lippincott Company, Philadelphia, 1990
[EC 188.8.131.52 created 1972 as EC 184.108.40.206, transferred 1978 as EC 220.127.116.11, part transferred 1992 to EC 18.104.22.168]