EC 3.4.21.68 - T-plasminogen activator

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IntEnz Enzyme Nomenclature
EC 3.4.21.68

Names

Accepted name:
t-plasminogen activator
Other names:
plasminogen activator, tissue-type
t-PA
tPA
tissue plasminogen activator
tissue-type plasminogen activator
Systematic name:
-

Reaction

Comments:

A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008243
CAS Registry Number: 139639-23-9 (not distinguished from EC 3.4.24.69)
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D.
    Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
    Nature 301: 214-221 (1983). [PMID: 6337343]
  2. Loskutoff, D.J. and Schleef, R.R.
    Plasminogen activators and their inhibitors.
    Methods Enzymol. 163: 293-302 (1988). [PMID: 3148826]
  3. Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E.
    The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage.
    Biochim. Biophys. Acta 952: 245-254 (1988). [PMID: 2962643]
  4. Verheijen, J.H.
    Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma.
    Methods Enzymol. 163: 302-309 (1988). [PMID: 3148827]
  5. Gerard, R.D. and Meidell, R.S.
    Regulation of tissue plasminogen activator expression.
    Annu. Rev. Physiol. 51: 245-262 (1989). [PMID: 2496643]
  6. Collen, D., Lijnen, H. R. and Verstraete, M.
    The fibrinolytic system and its disorders.
    In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.) Blood: Principles and Practice of Hematology, 2nd ed., J.B. Lippincott Company, Philadelphia, 1990

[EC 3.4.21.68 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.68]