EC - Kexin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Kex 2p proteinase
Kex2 endopeptidase
Kex2 endoprotease
Kex2 endoproteinase
Kex2 protease
Kex2 proteinase
Kex2-like endoproteinase
Kex2-like precursor protein processing endoprotease
andrenorphin-Gly-generating enzyme
endoproteinase Kex2p
gene KEX2 dibasic proteinase
paired-basic endopeptidase
prohormone-processing KEX2 proteinase
prohormone-processing endoprotease
prohormone-processing proteinase
proprotein convertase
protease KEX2
proteinase yscF
proteinase Kex2p
yeast KEX2 protease
yeast cysteine proteinase F [misleading]
Systematic name:



A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004290
CAS Registry Number: 99676-46-7


  1. Julius, D., Brake, A., Blair, L., Kunisawa, R. and Thorner, J.
    Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor.
    Cell 37: 1075-1089 (1984). [PMID: 6430565]
  2. Achstetter, T. and Wolf, D.H.
    Hormone processing and membrane-bound proteinases in yeast.
    EMBO J. 4: 173-177 (1985). [PMID: 3894003]
  3. Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H.
    Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases.
    Biochem. Biophys. Res. Commun. 156: 246-254 (1988). [PMID: 2845974]
  4. Fuller, R.S., Brake, A. and Thorner, J.
    Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
    Proc. Natl. Acad. Sci. USA 86: 1434-1438 (1989). [PMID: 2646633]
  5. Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H.
    Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae.
    Biochem. Biophys. Res. Commun. 159: 305-311 (1989). [PMID: 2845974]

[EC created 1989 as EC, transferred 1992 to EC]