EC - Endopeptidase La

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
endopeptidase La
Other names:
Escherichia coli proteinase La
Escherichia coli serine proteinase La
ATP-dependent lon proteinase
ATP-dependent protease La
ATP-dependent serine proteinase
PIM1 protease
PIM1 proteinase
gene lon protease
gene lon proteins
lon proteinase
protease La
proteinase La
serine protease La
Systematic name:



Product of the lon gene in Escherichia coli. ATP hydrolysis is linked with peptide bond hydrolysis; vanadate inhibits both reactions. Type example of peptidase family S16. A similar enzyme occurs in animal mitochondria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00803
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008846
CAS Registry Number: 79818-35-2
UniProtKB/Swiss-Prot: (190) [show] [UniProt]


  1. Desautels, M. and Goldberg, A.L.
    Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria.
    J. Biol. Chem. 257: 11673-11679 (1982). [PMID: 6749845]
  2. Larimore, F.S., Waxman, L. and Goldberg, A.L.
    Studies of the ATP-dependent proteolytic enzyme, protease La, from Escherichia coli.
    J. Biol. Chem. 257: 4187-4195 (1982). [PMID: 7040380]
  3. Chin, D.T., Goff, S.A., Webster, T., Smith, T. and Goldberg, A.L.
    Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La.
    J. Biol. Chem. 263: 11718-11728 (1988). [PMID: 3042779]

[EC created 1986]