EC 3.4.21.50 - Lysyl endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.21.50

Names

Accepted name:
lysyl endopeptidase
Other names:
Achromobacter lyticus alkaline proteinase I
Achromobacter proteinase I
achromopeptidase
lysyl bond specific proteinase
protease I
Systematic name:

Reaction

Comments:

From Achromobacter lyticus [6]. Enzymes with similar specificity are produced by Lysobacter enzymogenes (Endoproteinase Lys-C; [3]) and Pseudomonas aeruginosa (Ps-1; [4]). In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
CAS Registry Number: 123175-82-6
UniProtKB/Swiss-Prot:

References

  1. Masaki, T., Tanabe, M., Nakamura, K. and Soejima, M.
    Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1. I. Purification and some enzymatic properties.
    Biochim. Biophys. Acta 660: 44-50 (1981). [PMID: 6791693]
  2. Masaki, T., Fujihasi, T., Nakamura, K. and Soejima, M.
    Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1. II. Specificity and inhibition studies of Achromobacter protease I.
    Biochim. Biophys. Acta 660: 51-55 (1981). [PMID: 6168293]
  3. Jekel, P.A., Weijer, W.J. and Beintema, J.J.
    Use of endoproteinase Lys-C from Lysobacter enzymogenes in protein sequence analysis.
    Anal. Biochem. 134: 347-354 (1983). [PMID: 6359954]
  4. Elliott, B.W. and Cohen, C.
    Isolation and characterization of a lysine-specific protease from Pseudomonas aeruginosa.
    J. Biol. Chem. 261: 11259-11265 (1986). [PMID: 3090046]
  5. Ohara, T., Makino, K., Shinagawa, H., Nakata, A., Norioka, S. and Sakiyama, F.
    Cloning, nucleotide sequence, and expression of Achromobacter protease I gene.
    J. Biol. Chem. 264: 20625-20631 (1989). [PMID: 2684982]
  6. Tsunasawa, S., Masaki, T., Hirose, M., Soejima, M. and Sakiyama, F.
    The primary structure and structural characteristics of Achromobacter lyticus protease I, a lysine-specific serine protease.
    J. Biol. Chem. 264: 3832-3839 (1989). [PMID: 2492988]

[EC 3.4.21.50 created 1983]