EC 220.127.116.11 - Complement subcomponent C1̅s̅
IntEnz Enzyme Nomenclature
activated complement C1s
- Cleavage of Arg┼Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)┼Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase.
Activated from proenzyme C1̅s̅ in plasma by complement subcomponent C1̅r̅. In peptidase family S1 (trypsin family).
Links to other databases
The human complement system serine proteases C1̅r̅ and C1̅s̅ and their proenzymes.Methods Enzymol. 80C: 26-42 (1981). [PMID: 6281620]
Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.Eur. J. Biochem. 169: 547-553 (1987). [PMID: 3500856]
Molecular organization and function of the complement system.Annu. Rev. Biochem. 57: 321-347 (1988). [PMID: 3052276]
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.Biochim. Biophys. Acta 996: 89-94 (1989). [PMID: 2500154]
[EC 18.104.22.168 created 1981]