EC 184.108.40.206 - Complement subcomponent C1̅r̅
IntEnz Enzyme Nomenclature
activated complement C1r
- Selective cleavage of Lys(or Arg)┼Ile bond in complement subcomponent C1s to form C1̅s̅ (EC 220.127.116.11).
Activated from proenzyme C1̅r̅ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family).
Links to other databases
The human complement system serine proteases C1̅r̅ and C1̅s̅ and their proenzymes.Methods Enzymol. 80C: 26-42 (1981). [PMID: 6281620]
Nucleotide sequence of the cDNA coding for human complement C1r.Biochemistry 25: 4855-4863 (1986). [PMID: 3021205]
Molecular organization and function of the complement system.Annu. Rev. Biochem. 57: 321-347 (1988). [PMID: 3052276]
[EC 18.104.22.168 created 1981]