EC - Leukocyte elastase

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IntEnz Enzyme Nomenclature


Accepted name:
leukocyte elastase
Other names:
granulocyte elastase
lysosomal elastase
neutrophil elastase
polymorphonuclear leukocyte elastase
serine elastase
bone marrow serine protease
Systematic name:



Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
CAS Registry Number: 9004-06-2


  1. Barrett, A.J.
    Leukocyte elastase.
    Methods Enzymol. 80C: 581-588 (1981). [PMID: 7043201]
  2. Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C.
    Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
    Biochemistry 23: 2995-3002 (1984). [PMID: 6380580]
  3. Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C.
    Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
    Biochemistry 26: 1301-1305 (1987). [PMID: 3646070]
  4. Bode, W., Meyer, E., Jr. and Powers, J.C.
    Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
    Biochemistry 28: 1951-1963 (1989). [PMID: 2655701]

[EC created 1981 (EC created 1961, transferred 1972 to EC created 1972, part incorporated 1984)]