EC 3.4.21.37 - Leukocyte elastase

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IntEnz Enzyme Nomenclature
EC 3.4.21.37

Names

Accepted name:
leukocyte elastase
Other names:
elastase
elaszym
granulocyte elastase
lysosomal elastase
neutrophil elastase
polymorphonuclear leukocyte elastase
serine elastase
medullasin
bone marrow serine protease
Systematic name:
-

Reaction

Comments:

Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
CAS Registry Number: 9004-06-2
UniProtKB/Swiss-Prot:

References

  1. Barrett, A.J.
    Leukocyte elastase.
    Methods Enzymol. 80C: 581-588 (1981). [PMID: 7043201]
  2. Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C.
    Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
    Biochemistry 23: 2995-3002 (1984). [PMID: 6380580]
  3. Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C.
    Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
    Biochemistry 26: 1301-1305 (1987). [PMID: 3646070]
  4. Bode, W., Meyer, E., Jr. and Powers, J.C.
    Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
    Biochemistry 28: 1951-1963 (1989). [PMID: 2655701]

[EC 3.4.21.37 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)]