EC 3.4.21.34 - Plasma kallikrein

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IntEnz Enzyme Nomenclature
EC 3.4.21.34

Names

Accepted name:
plasma kallikrein
Other names:
bradykininogenase
callicrein
depot-Padutin
dilminal D
glumorin
kallidinogenase
kallikrein
kallikrein I
kallikrein II
kininogenase
kininogenin
onokrein P
padreatin
padutin
panceatic kallikrein
serum kallikrein
urinary kallikrein
urokallikrein
Systematic name:
-

Reaction

Comments:

Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates. In peptidase family S1 (trypsin family). Formerly EC 3.4.4.21 and included in EC 3.4.21.8.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124 , PROSITE:PDOC00376
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003807
CAS Registry Number: 9001-01-8 (not distinguished from EC 3.4.21.32 and EC 3.4.21.34)
UniProtKB/Swiss-Prot:

References

  1. Heimark, R.L. and Davie, E.W.
    Bovine and human plasma prekallikrein.
    Methods Enzymol. 80C: 157-172 (1981). [PMID: 6918767]
  2. McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C.
    Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.
    Biochemistry 20: 7196-7206 (1981). [PMID: 6976185]
  3. Silverberg, M. and Kaplan, A.P.
    Prekallikrein.
    Methods Enzymol. 163: 85-95 (1988). [PMID: 3237096]
  4. Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M.
    The cDNA structure of rat plasma kallikrein.
    DNA 8: 563-574 (1989). [PMID: 2598771]
  5. Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S.
    Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein.
    Chem. Pharm. Bull. 37: 3108-3111 (1989). [PMID: 2534361]

[EC 3.4.21.34 created 1965 as EC 3.4.4.21, transferred 1972 to 3.4.21.8, part transferred 1981 to EC 3.4.21.34]