EC 3.4.21.104 - Mannan-binding lectin-associated serine protease-2

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IntEnz Enzyme Nomenclature
EC 3.4.21.104

Names

Accepted name:
mannan-binding lectin-associated serine protease-2
Other names:
MASP-2
MBP-associated serine protease-2
mannose-binding lectin-associated serine protease-2
p100
mannan-binding lectin-associated serine peptidase 2
MASP2
Systematic name:
-

Reaction

Comments:

Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement [7]. This enzyme displays C1̅s̅-like esterolytic activity (cf. EC 3.4.21.42, complement subcomponent C1̅s̅). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42 [3]. Belongs in peptidase family S1A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Matsushita, M. and Fujita, T.
    Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease.
    J. Exp. Med. 176: 1497-1502 (1993). [PMID: 1460414]
  2. Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B.M. and Jensenius, J.C.
    A second serine protease associated with mannan-binding lectin that activates complement.
    Nature 386: 506-510 (1997). [PMID: 9087411]
  3. Rossi, V., Cseh, S., Bally, I., Thielens, N.M., Jensenius, J.C. and Arlaud, G.J.
    Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.
    J. Biol. Chem. 276: 40880-40887 (2001). [PMID: 11527969]
  4. Ambrus, G., Gál, P., Kojima, M., Szilágyi, K., Balczer, J., Antal, J., Gráf, L., Laich, A., Moffatt, B. E., Schwaeble, W., Sim, R.B. and Závodszky, P.
    Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.
    J. Immunol. 170: 1374-1382 (2003). [PMID: 12538697]
  5. Harmat, V., Gál, P., Kardos, J., Szilágyi, K., Ambrus, G., Végh, B., Náray-Szabó, G. and Závodszky, P.
    The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.
    J. Mol. Biol. 342: 1533-1546 (2004). [PMID: 15364579]
  6. Chen, C.-B. and Wallis, R.
    Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.
    J. Biol. Chem. 279: 26058-26065 (2004). [PMID: 15060079]
  7. Teillet, F., Dublet, B., Andrieu, J.-P., Gaboriaud, C., Arlaud, G.J and Thielens, N.M.
    The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases.
    J. Immunol. 174: 2870-2877 (2005). [PMID: 15728497]

[EC 3.4.21.104 created 2005]