EC - C-terminal processing peptidase

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IntEnz Enzyme Nomenclature


Accepted name:
C-terminal processing peptidase
Other names:
CtpA gene product (Synechocystis sp.)
Tsp protease
photosystem II D1 protein processing peptidase
protease Re
tail-specific protease
Systematic name:



Proteolytic processing of the D1 protein of photosystem II is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The recognition of the substrate is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. Type example of peptidase family S41.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019132
CAS Registry Number: 113356-29-9
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Keiler, K.C. and Sauer, R.T.
    Tsp protease.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 460-461
  2. Beebe, K.D., Shin, J.N., Peng, J., Chaudhury, C., Khera, J. and Pei, D.H.
    Substrate recognition through a PDZ domain in tail-specific protease.
    Biochemistry 39: 3149-3155 (2000). [PMID: 10715137]
  3. Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B. and Diner, B.A.
    Crystal structures of the photosystem II D1 C-terminal processing protease.
    Nat. Struct. Biol. 7: 749-753 (2000). [PMID: 10966643]

[EC created 2001]