EC 3.4.17.3 - Lysine carboxypeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.17.3

Names

Accepted name:
lysine carboxypeptidase
Other names:
CPase N
anaphylatoxin inactivator
arginine carboxypeptidase
bradykinase
bradykinin-decomposing enzyme
carboxypeptidase N
creatine kinase conversion factor
creatinine kinase convertase
hippuryllysine hydrolase
kininase I
kininase Ia
peptidyl-L-lysine(-L-arginine) hydrolase
plasma carboxypeptidase B
protaminase
lysine(arginine) carboxypeptidase
Systematic name:
-

Reaction

Cofactor

Comments:

A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family). Formerly EC 3.4.12.7.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00123
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004184
CAS Registry Number: 9013-89-2
UniProtKB/Swiss-Prot:

References

  1. Plummer, T.H., Jr and Erdös, E.G.
    Human plasma carboxypeptidase N.
    Methods Enzymol. 80C: 442-449 (1981). [PMID: 7341915]
  2. Levin, Y., Skidgel, R.A. and Erdös, E.G.
    Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I).
    Proc. Natl. Acad. Sci. USA 79: 4618-4622 (1982). [PMID: 6750606]
  3. Skidgel, R.A.
    Basic carboxypeptidases: regulators of peptide hormone activity.
    Trends Pharmacol. Sci. 9: 301-303 (1988). [PMID: 3074547]

[EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989]