EC - Metallocarboxypeptidase D

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IntEnz Enzyme Nomenclature


Accepted name:
metallocarboxypeptidase D
Other names:
carboxypeptidase D (cattle, human, mouse, rat)
gp180 (duck)
Systematic name:




Activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008472
CAS Registry Number: 153967-26-1


  1. Kuroki, K., Eng, F., Ishikawa, T., Turck, C., Harada, F. and Ganem, D.
    gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family.
    J. Biol. Chem. 270: 15022-15028 (1995). [PMID: 9525948]
  2. Song, L.X. and Fricker, L.D.
    Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary.
    J. Biol. Chem. 270: 25007-25013 (1995). [PMID: 7559630]
  3. Song, L.X. and Fricker, L.D.
    Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D.
    J. Biol. Chem. 271: 28884-28889 (1996). [PMID: 8910535]

[EC created 1997]