EC 184.108.40.206 - Metallocarboxypeptidase D
IntEnz Enzyme Nomenclature
- Releases C-terminal Arg and Lys from polypeptides.
Activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family).
Links to other databases
gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family.J. Biol. Chem. 270: 15022-15028 (1995). [PMID: 9525948]
Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary.J. Biol. Chem. 270: 25007-25013 (1995). [PMID: 7559630]
Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D.J. Biol. Chem. 271: 28884-28889 (1996). [PMID: 8910535]
[EC 220.127.116.11 created 1997]