EC 3.4.17.2 - Carboxypeptidase B

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IntEnz Enzyme Nomenclature
EC 3.4.17.2

Names

Accepted name:
carboxypeptidase B
Other names:
pancreatic carboxypeptidase B
peptidyl-L-lysine [L-arginine]hydrolase
protaminase
tissue carboxypeptidase B
Systematic name:

Reaction

Cofactor

Comments:

A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family). Formerly EC 3.4.2.2 and 3.4.12.3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00123
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050425
CAS Registry Number: 9025-24-5
UniProtKB/Swiss-Prot:

References

  1. Folk, J.E.
    Carboxypeptidase B (porcine pancreas).
    Methods Enzymol. 19: 504-508 (1970).
  2. Brodrick, J.W., Geokas, M.C. and Largman, C.
    Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
    Biochim. Biophys. Acta 452: 468-481 (1976). [PMID: 1009123]
  3. Butterworth, J. and Duncan, J.J.
    Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
    Clin. Chim. Acta 97: 39-43 (1979). [PMID: 40714]
  4. Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D.
    Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?
    Life Sci. 31: 1793-1796 (1982). [PMID: 6130442]

[EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2]