EC 3.4.17.12 - Carboxypeptidase M

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IntEnz Enzyme Nomenclature
EC 3.4.17.12

Names

Accepted name:
carboxypeptidase M
Other name:
CPM
Systematic name:

Reaction

Cofactor

Comments:

A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00123
Structural data: CSA , EC2PDB
CAS Registry Number: 120038-28-0
UniProtKB/Swiss-Prot:

References

  1. Skidgel, R.A.
    Basic carboxypeptidases: Regulators of peptide hormone activity.
    Trends Pharmacol. Sci. 9: 303-304 (1988). [PMID: 3074547]
  2. Deddish, P.A., Skidgel, R.A. and Erdös, E.G.
    Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH.
    Biochem. J. 261: 289-291 (1989). [PMID: 2775217]
  3. Skidgel, R.A., Davis, R.M. and Tan, F.
    Human carboxypeptidase M. Purification and characterization of membrane-bound carboxypeptidase that cleaves peptide hormones.
    J. Biol. Chem. 264: 2236-2241 (1989). [PMID: 2914904]

[EC 3.4.17.12 created 1992]