EC 184.108.40.206 - Serine-type D-Ala-D-Ala carboxypeptidase
IntEnz Enzyme Nomenclature
- Preferential cleavage: (Ac)2-L-Lys-D-Ala┼D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
A membrane-bound, bacterial enzyme inhibited by penicillin and other β-lactam antibiotics, which acylate the active site serine. Examples are known from peptidase families S11, S12 and S13. Distinct from zinc D-Ala-D-Ala carboxypeptidase, EC 220.127.116.11.
Links to other databases
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.Scand. J. Infect. Dis. 42: 17-37 (1984). [PMID: 6597561]
Penicillin-sensitive enzymes in peptidoglycan biosynthesis.CRC Crit. Rev. Microbiol. 11: 306-331 (1985). [PMID: 3888533]
[EC 18.104.22.168 created 1989]