EC - Xaa-Pro dipeptidyl-peptidase

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IntEnz Enzyme Nomenclature


Accepted name:
Xaa-Pro dipeptidyl-peptidase
Other names:
X-Pro dipeptidyl-peptidase
X-prolyl dipeptidyl aminopeptidase
X-prolyl dipeptidyl peptidase
Systematic name:



The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. The reaction is similar to that catalysed by dipeptidyl-peptidase IV of animals.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017088
CAS Registry Number: 54249-88-6
UniProtKB/Swiss-Prot: (60) [show] [UniProt]


  1. Zevaco, C., Monnet, V. and Gripon, J.-C.
    Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis spp. lactis: purification and properties.
    J. Appl. Bacteriol. 68: 357-366 (1990).
  2. Meyer-Barton, E.C., Klein, J.R., Imam, M. and Plapp, R.
    Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbrückii ssp. lactis DSM7290.
    Appl. Microbiol. Biotechnol. 40: 82-89 (1993). [PMID: 7765315]
  3. Habibi-Najafi, M.B. and Lee, B.H.
    Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei subsp. casei LLG.
    Appl. Microbiol. Biotechnol. 42: 280-286 (1994). [PMID: 7765768]
  4. Chich, J.-F., Gripon, J.-C. and Ribadeau-Dumas, B.
    Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents.
    Anal. Biochem. 224: 245-249 (1995). [PMID: 7710078]
  5. Chich, J.-F., Chapot-Chartier, M.P., Ribadeau-Dumas, B. and Gripon, J.-C.
    Identification of the active site serine of the X-prolyl aminopeptidase from Lactococcus lactis.
    FEBS Lett. 314: 139-142 (1995).

[EC created 1996]