EC 3.4.11.1 - Leucyl aminopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.11.1

Names

Accepted name:
leucyl aminopeptidase
Other names:
L-leucine aminopeptidase
FTBL proteins
aminopeptidase I
aminopeptidase II
aminopeptidase III
cathepsin III
cytosol aminopeptidase
leucinamide aminopeptidase
leucinaminopeptidase
leucine aminopeptidase
leucyl peptidase
peptidase S
proteinates FTBL
Systematic name:

Reaction

Cofactor

Comments:

A zinc enzyme isolated from pig kidney and cattle lens; activated by heavy metal ions. Type example of peptidase family M17. Formerly EC 3.4.1.1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00548
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004178
CAS Registry Numbers: 9001-61-0 90119-07-6
UniProtKB/Swiss-Prot: (438) [show] [UniProt]

References

  1. Himmelhoch, S.R.
    Leucine aminopeptidase from swine kidney.
    Methods Enzymol. 19: 508-513 (1970).
  2. Delange, R.J. and Smith, E.L.
    Leucine aminopeptidase and other N-terminal exopeptidases.
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 3, Academic Press, New York, 1971, 88-118
  3. van Loon-Klaasen, L.A.H., Cuypers, H.T., van Westreenen, H., de Jong, W.W. and Bloemendal, H.
    The primary structure of bovine lens leucine aminopeptidase. Complete amino acid sequence of the N-terminal cyanogen bromide fragment and site limited tryptic digestion.
    Biochem. Biophys. Res. Commun. 95: 334-341 (1980). [PMID: 7417261]

[EC 3.4.11.1 created 1961 as EC 3.4.1.1, transferred 1972 to EC 3.4.11.1]