EC 3.3.1.1 - Adenosylhomocysteinase

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IntEnz Enzyme Nomenclature
EC 3.3.1.1

Names

Accepted name:
adenosylhomocysteinase
Other names:
S-adenosylhomocysteinase
S-adenosylhomocysteine hydrolase
S-adenosylhomocysteine synthase
AdoHcyase
SAHase
adenosylhomocysteine hydrolase
Systematic name:
S-adenosyl-L-homocysteine hydrolase

Reaction

Cofactor

Comments:

The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond [2], cf. EC 5.5.1.4, inositol-3-phosphate synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00603
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004013
CAS Registry Number: 9025-54-1
UniProtKB/Swiss-Prot: (251) [show] [UniProt]

References

  1. de la Haba, G. and Cantoni, G.L.
    The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine.
    J. Biol. Chem. 234: 603-608 (1959). [PMID: 13641268]
  2. Palmer, J.L. and Abeles, R.H.
    The mechanism of action of S-adenosylhomocysteinase.
    J. Biol. Chem. 254: 1217-1226 (1979). [PMID: 762125]

[EC 3.3.1.1 created 1961, modified 2004]