EC - Adenosylhomocysteine nucleosidase

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IntEnz Enzyme Nomenclature


Accepted name:
adenosylhomocysteine nucleosidase
Other names:
5'-methyladenosine nucleosidase
S-adenosylhomocysteine hydrolase [ambiguous]
S-adenosylhomocysteine nucleosidase
S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase
AdoHcy/MTA nucleosidase
Systematic name:
S-adenosyl-L-homocysteine homocysteinylribohydrolase



Also acts on S-methyl-5'-thioadenosine to give adenine and S-methyl-5-thioribose (cf. EC, methylthioadenosine nucleosidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008782
CAS Registry Number: 9055-10-1
UniProtKB/Swiss-Prot: (195) [show] [UniProt]


  1. Duerre, J.A.
    A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine.
    J. Biol. Chem. 237: 3737-3741 (1962).
  2. Ferro, A.J., Barrett, A. and Shapiro, S.K.
    Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli.
    Biochim. Biophys. Acta 438: 487-494 (1976). [PMID: 782530]
  3. Choi-Rhee, E., Cronan, J. E.
    A nucleosidase required for in vivo function of the S-adenosyl-L-methionine radical enzyme, biotin synthase.
    Chem. Biol. 12: 589-593 (2005). [PMID: 15911379]
  4. Farrar, C. E., Siu, K. K., Howell, P. L., Jarrett, J. T.
    Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.
    Biochemistry 49: 9985-9996 (2010). [PMID: 20961145]

[EC created 1972, modified 2004]