EC 3.2.2.23 - DNA-formamidopyrimidine glycosylase

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IntEnz Enzyme Nomenclature
EC 3.2.2.23

Names

Accepted name:
DNA-formamidopyrimidine glycosylase
Other names:
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase
2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase
Fapy-DNA glycosylase
Fpg protein
deoxyribonucleate glycosidase
formamidopyrimidine-DNA glycosylase
Systematic name:
DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]

Reaction

Comments:

May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00956
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008534
UniProtKB/Swiss-Prot: (453) [show] [UniProt]

References

  1. Boiteux, S., O'Connor, T.R. and Laval J.
    Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.
    EMBO J. 6: 3177-3183 (1987). [PMID: 3319582]

[EC 3.2.2.23 created 1990, modified 2000]