EC 3.2.2.21 - DNA-3-methyladenine glycosylase II

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IntEnz Enzyme Nomenclature
EC 3.2.2.21

Names

Accepted name:
DNA-3-methyladenine glycosylase II
Other names:
3-methyladenine DNA glycosylase II
AlkA
DNA-3-methyladenine glycosidase II
deoxyribonucleate 3-methyladenine glycosidase II
DNA glycosidase II
Systematic name:
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)

Reaction

Comments:

Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00447
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008725 , GO:0052822 , GO:0052821 , GO:0043916 , GO:0003905
CAS Registry Number: 89287-38-7
UniProtKB/Swiss-Prot: (13) [show] [UniProt]

References

  1. Evensen, G. and Seeberg, E.
    Adaptation to alkylation resistance involves the induction of a DNA glycosylase.
    Nature 296: 773-775 (1982). [PMID: 7040984]
  2. Karran, P., Hjelmgren, T. and Lindahl, T.
    Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.
    Nature 296: 770-773 (1982). [PMID: 7040983]
  3. Riazuddin, S. and Lindahl, T.
    Properties of 3-methyladenine-DNA glycosylase from Escherichia coli.
    Biochemistry 17: 2110-2118 (1978). [PMID: 352392]
  4. Thomas, L., Yang, C.-H. and Goldthwait, D.A.
    Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine.
    Biochemistry 21: 1162-1169 (1982). [PMID: 7041972]

[EC 3.2.2.21 created 1990, modified 2000]