EC 3.2.1.62 - Glycosylceramidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.2.1.62

Names

Accepted name:
glycosylceramidase
Other names:
cerebrosidase
glycosyl ceramide glycosylhydrolase
lactase-phlorizin hydrolase
phloretin-glucosidase
phloridzin β-glucosidase
phloridzin glucosidase
phlorizin hydrolase
Systematic name:
glycosyl-N-acylsphingosine glycohydrolase

Reaction

Comments:

Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00495
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017042
CAS Registry Number: 9033-10-7
UniProtKB/Swiss-Prot:

References

  1. Leese, H.J. and Semenza, G.
    On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase.
    J. Biol. Chem. 248: 8170-8173 (1973). [PMID: 4752949]
  2. Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G.
    A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase.
    Eur. J. Clin. Invest. 2: 326-331 (1972). [PMID: 5082068]
  3. Malathi, P. and Crane, R.K.
    Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane.
    Biochim. Biophys. Acta 173: 245-256 (1969). [PMID: 5774775]

[EC 3.2.1.62 created 1972, modified 1976]